| Assay no | Test | Verbal results within |
|---|
| BT 403 | Assay for Viral Contaminants using Embryonated Eggs
- Assay in compliance with European and US guidelines for mammalian cell lines
- Inoculation of embryonated eggs by multiple routes followed by passages
- Concurrent positive and negative controls | 5 weeks |
| BT 403A | Test for extraneous agents in viral vaccines using Embryonated Eggs
- Assay in compliance with FDA guidelines for the production of viral vaccines for the prevention and treatment of infectious diseases
- Neutralization procedures if required
- Inoculation of embryonated eggs by multiple routes followed by passages
- Concurrent positive and negative controls |  |
| BT 404A | Assay for Viral Contaminants using Rodents
- Inoculation of adult mice, newborn mice and guinea-pigs by multiple routes
- Observation for clinical symptoms of viral infection | 4 weeks |
| BT 404B | Assay for Viral Contaminants using Adult and Newborn Mice
- Inoculation of adult mice, newborn mice by multiple routes
- Observation for clinical symptoms of viral infection | 4 weeks |
| BT 405 | Extended Assay for Viral Contaminants using Indicator Cell Lines
- Inoculation into an extended series of indicator cell lines, followed by a passage (amplification step)
- A series of five cell lines are included, aimed at the detection of a broad array of viruses infectious for different mammalian cell lines
- Tests for hemagglutinating and hemadsorbing viruses
- Concurrent positive and negative controls | 4 weeks |
| BT 406A | Assay for Viral Contaminants using 3 Indicator Cell Lines (Mouse)
- Inoculation onto three indicator cell lines aimed at the detection of mouse specific viruses
- Procedure identical to Assay #BT405 | 4 weeks |
| BT 406B | Assay for Viral Contaminants using 3 Indicator Cell Lines (Human)
- Inoculation onto three indicator cell lines aimed at the detection of human specific viruses
- Procedure identical to Assay #BT405 | 4 weeks |
| BT 406C | Assay for Viral Contaminants using 3 Indicator Cell Lines (Hamster)
- Inoculation onto three indicator cell lines aimed at the detection of hamster specific viruses
- Procedure identical to Assay #BT405 | 4 weeks |
| BT 406D | Assay for Viral Contaminants using 3 Indicator Cell Lines (Bovine)
- Inoculation onto three indicator cell lines aimed at the detection of bovine specific viruses
- Procedure identical to Assay #BT405 | 4 weeks |